Fibronectin Expression in the Intervertebral Disc of Monkey

ISSN: 2212-3946 (Online)
ISSN: 1574-888X (Print)


Volume 9, 6 Issues, 2014


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Fibronectin Expression in the Intervertebral Disc of Monkey

Author(s): Umile Giuseppe Longo, Purification Ripalda, Giuseppe Salvatore, Alessandra Berton, Wasim Sardar Khan, Nicola Maffulli, Francisco Forriol and Vincenzo Denaro

Affiliation: Department of Orthopaedic and Trauma Surgery Campus Bio-Medico University Via Alvaro del Portillo, 200 00128 Trigoria, Rome, Italy

Abstract

Background: Fibronectin, a large dimeric plasma glycoprotein found only in vertebrates, is a core component of many extracellular matrices, where it regulates a variety of cell activities through direct interactions with cell surface integrin receptors. Little is known of fibronectin expression patterns in intervertebral disc. The aim of this study was to evaluate the distribution of fibronectin in the different regions of the intervertebral disc, and in intervertebral discs of different levels of monkeys Methods: Forty-five vertebral motion segments were obtained from the spine of nine 3-4 year-old cynomolgus monkeys (Macaca fascicularis). From every spine, 5 vertebral motion segments were later sectioned (C5-C6, T3-T4, T9-T10, L2-L3, L4-L5) and cut in half through a medial sagittal cut. Immunohistochemistry was performed, using specific antibodies to detect fibronectin. Results: A positive immunoreaction for fibronectin was found in the endplates, in the outer annulus fibrosus, and in the longitudinal ligaments. There was no fibronectin immunoreactivity in the nucleus pulposus and in the annular region close to the nucleus pulposus. There were no differences in immunoreactivity to fibronectin among discs of different levels and discs of different monkeys. Conclusions: Fibronectin may exert a role in the organization of the extracellular matrix in the intervertebral discs. Identifying the structural features of the extracellular matrix of the intervertebral disc may help to understand the mechanisms of intervertebral disc pathology


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Article Details

Volume: 9
First Page: 1
Page Count: 1
DOI: 10.2174/1574888X09666140710114414
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