Unravelling the Genetic Susceptibility to Develop Ligament and Tendon Injuries

ISSN: 2212-3946 (Online)
ISSN: 1574-888X (Print)


Volume 9, 6 Issues, 2014


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Current Stem Cell Research & Therapy

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Wake Forest University School of Medicine,
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Winston Salem, NC 27157
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Unravelling the Genetic Susceptibility to Develop Ligament and Tendon Injuries

Author(s): Umile Giuseppe Longo, Mattia Loppini, Katia Margiotti, Giuseppe Salvatore, Alessandra Berton, Wasim S Khan, Nicola Maffulli and Vincenzo Denaro

Affiliation: Department of Orthopaedic and Trauma Surgery Campus Bio-Medico University Via Alvaro del Portillo, 200 00128 Trigoria, Rome, Italy

Abstract

Purpose: In the last decades, new evidences supported the relationship polymorphisms and the susceptibility to develop ligament and tendon injuries. We performed a review of the genetic factors involved in tendon and ligament injuries. Methods: We performed a systematic review of the literature using the terms “sports”, ”ligaments”, “injuries”, “tendon” and “genetics”. A comprehensive search of PubMed, Medline, CINAHL, Cochrane, Embase and Google Scholar databases was performed over the years 1984–2014. Results: The genes currently associated with tendon and ligament injuries include gene encoding for collagen, tenascin, matrix metallopeptidase, and growth factors. Conclusions: Tendon and ligament injuries do not have a single genetic cause. They are associated with the effects of multiple genes in combination with lifestyle and environmental factors. Although complex disorders often cluster in families, they do not have a clear-cut pattern of inheritance. This makes it difficult to determine a person’s risk of inheriting or passing on these disorders. Complex disorders are also difficult to study and treat because the specific factors that cause most of these disorders have not yet been identified. Researchers continue to look for major contributing genes for many common complex disorders


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Article Details

Volume: 9
First Page: 1
Page Count: 1
DOI: 10.2174/1574888X09666140710112535
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