Significance of Biotic Factors in Mesenchymal Stem Cell Fate in Regenerative Medicine

ISSN: 2212-3946 (Online)
ISSN: 1574-888X (Print)


Volume 9, 6 Issues, 2014


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Wake Forest University School of Medicine,
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Significance of Biotic Factors in Mesenchymal Stem Cell Fate in Regenerative Medicine

Author(s): Rama Raju Baadhe, Naveen Kumar Mekala and Ravichandra Potumarthi

Affiliation: Department of Biotechnology, National Institute of Technology, Warangal, India

Abstract

Stem and progenitor cell research is a complex and very exciting field that promises fantastic curative discoveries in numerous areas from cancer to diabetes to regenerative medicine. The use of biotic factors or growth factors has played an essential role in the development of stem cell research. These biologically active components have been administered into stem cells either to improve or maintain the stem cell proliferation, or to encourage controlled differentiation into more defined cell types. Small molecules like 6-Bromoindirubin-3´-oxime (BIO), cardiogenol-C, etc can really help stem cell research by controlling or influencing the regulatory changes in a controlled manner and to help understand the mechanisms during stem cell differentiation. Extra cellular matrix (ECM) is another significant biotic factor, which mediate cell and tissue behavior by influencing cell-matrix interactions. Thus, in this review we would like to emphasize significance of various growth factors in stem cell research


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Article Details

Volume: 9
First Page: 1
Last Page: 1
Page Count: 1
DOI: 10.2174/1574888X09666140507124727
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