Perfusion Method for Intra-bone Marrow Collection and Stem Cell Transplantation: A Critical Review

ISSN: 2212-3946 (Online)
ISSN: 1574-888X (Print)

Volume 10, 6 Issues, 2015

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Current Stem Cell Research & Therapy

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Anthony Atala
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157

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Perfusion Method for Intra-bone Marrow Collection and Stem Cell Transplantation: A Critical Review

Current Stem Cell Research & Therapy , Volume 9 (E-pub ahead of print)

Author(s): Narasimhulu Korrapati and Harikrishna Yadav Nanganuru.

Affiliation: Department of Biotechnology National Institute of Technology Warangal Warangal-506004, India


A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Bone marrow is the soft, fatty tissue inside our bones. Bone marrow transplantation (BMT) is a powerful strategy for the treatment of leukemia, aplastic anemia, congenital immunodeficiency and autoimmune diseases. In humans, bone marrow cells (BMCs) have usually been collected by multiple bone marrow aspirations from the iliac crest. We have established a new “perfusion” method for collecting BMCs with minimal contamination with the peripheral blood using the long bones of cynomolgus monkeys. This method has proven to be a simple and safe method for harvesting BMCs and reduces the risk of acute graft versus host disease in allogeneic BMT. Intra-bone marrow-BMT (IBM-BMT) provides distinct advantages because it recruits donor-derived hematopoietic stem cells and mesenchymal stem cells. IBM-BMT has been shown to currently be the best strategy for allogeneic BMT. Here we review the perfusion method (for harvesting BMCs) and IBM-BMT (for their transplantation) and show that this combination will become a powerful new clinical strategy for allogeneic BMT

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Article Details

Volume: 9
First Page: 1
Page Count: 1
DOI: 10.2174/1574888X09666140319153110

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