Cancer Cells and Cancer Stem Cells. Comparing their Growth Curves

ISSN: 2212-3946 (Online)
ISSN: 1574-888X (Print)

Volume 10, 6 Issues, 2015

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Current Stem Cell Research & Therapy

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Anthony Atala
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157

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Cancer Cells and Cancer Stem Cells. Comparing their Growth Curves

Current Stem Cell Research & Therapy , Volume 9 (E-pub ahead of print)

Author(s): Maria Toloudi, Eleni Ioannou, Marina Chatziioannou, Panagiotis Apostolou, Christos Kiritsis, Stella Manta, Dimitri Komiotis and Ioannis Papasotiriou.

Affiliation: Department of Biochemistry and Molecular Biology Research Genetic Cancer Centre Ltd (R.G.C.C. Ltd) 115 M. Alexandrou str., 53070 Filotas Florina Greece


Background: A basic problem in cancer research is identifying the cells responsible for tumour formation. The latest avenue of research is revealing the existence of and role for the cancer stem cell (CSC) model, which promotes the idea that malignancies originate from a small fraction of cancer cells that show self-renewal and multi- or pluripotency. The identification of this ‘cancer stem cell’ population has important implications for the management of cancer patients. This includes diagnostic and predictive laboratory assays, as well as novel therapeutic strategies specifically targeting the cancer stem cell. Materials and Methods: In this study, it was investigated the growth rate of this CSCs population and was compared with this of the commercial cancer cells. In order the growth curves to be formed, blood derived CSCs were isolated from patients who suffer from three types of cancer, breast colon and lung and cultured in culture flasks. Real- Time PCR was used as the molecular- based method for indicating the CSCs existence in the samples. Conclusion: It was shown that CSCs do not follow the common pattern of a typical mammalian cell growth curve in contrast with commercial cancer cells. This observation, that CSCs are rapidly growing, indicates their ability to involve in tumor formation

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Article Details

Volume: 9
First Page: 1
Page Count: 1
DOI: 10.2174/1574888X09666131217003412

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