From Raynaud’s Phenomenon to Very Early Diagnosis of Systemic Sclerosis- The VEDOSS approach

ISSN: 1875-6360 (Online)
ISSN: 1573-3971 (Print)

Volume 13, 3 Issues, 2017

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Current Rheumatology Reviews

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Dr. Serena Guiducci
Department of Biomedicine, Division of Rheumatology
University of Florence

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From Raynaud’s Phenomenon to Very Early Diagnosis of Systemic Sclerosis- The VEDOSS approach

Current Rheumatology Reviews, 9(4): 245-248.

Author(s): Silvia Bellando-Randone and Marco Matucci-Cerinic.

Affiliation: Department Rheumatology AVC, Department Biomedicine AOUC, Division Rheumatology AOUC, Department Medicine Denothe Centre, University of Florence, Italy, Villa Monna Tessa, Viale Pieraccini 18, 50139 Firenze Italy.


Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that is very difficult to diagnose in the early phase, because of the low sensitivity of the classification criteria currently used to identify patients without skin involvement, with an important delay on the therapy that is often started when internal organ involvement has already irreversible. The biggest challenge in the fight against SSc is to detect valid predictors of disease so as to treat patients since the earliest stages of disease. Raynaud’s phenomenon (RP), antinuclear antibodies (ANA) positivity, and puffy fingers have been recently indicated as the“red flags”, the main elements to suspect SSc and then to perform further tests to confirm the diagnosis in particular nailfold video capillaroscopy and evaluation of specific disease antibodies (anticentromere and anti-topoisomerase I).

Particularly, RP is the earliest, even if aspecific sign of SSc, and more and more attention should be paid to its early identification in order to reduce the diagnostic delay. Besides, the time gap between the onset of RP and the diagnosis should be considered as a “window of opportunity” for SSc patients, through which the physician can act with effective drugs able to block or at least slow the progression of the disease.


Systemic sclerosis, early diagnosis, Raynaud’s phenomenon, VEDOSS.

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Article Details

Volume: 9
Issue Number: 4
First Page: 245
Last Page: 248
Page Count: 4
DOI: 10.2174/157339710904140417124819
Price: $58

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