Nonalcoholic Fatty Liver Disease In Children: Recent Practice Guidelines, Where Do They Take Us?

ISSN: 1875-6336 (Online)
ISSN: 1573-3963 (Print)


Volume 10, 4 Issues, 2014


Download PDF Flyer




Current Pediatric Reviews

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Giuseppe Buonocore
Department of Molecular and Developmental Medicine
University of Siena
Siena
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Nonalcoholic Fatty Liver Disease In Children: Recent Practice Guidelines, Where Do They Take Us?

Author(s): Ashish Aggarwal, Kanika Puri, Suraj Thangada, Nizar Zein and Naim Alkhouri

Affiliation: Department of Pediatric Gastroenterology, A-111, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children and adolescents in the United States. It is strongly associated with childhood obesity, insulin resistance and metabolic syndrome. Although some children with NAFLD may remain asymptomatic, progression to nonalcoholic steatohepatitis (NASH), and to advanced stages of fibrosis and cirrhosis is well recognized. Unfortunately, despite the increase in awareness of this disease, there are still no reliable non-invasive diagnostic tests and liver biopsy remains the gold standard for the diagnosis of NASH and staging of fibrosis. In addition, there are no approved pharmacological treatments currently. Lifestyle modification remains the cornerstone of treatment. Team based multidisciplinary approach involving hepatologists, endocrinologists, exercise physiologist, dieticians, and cardiologists may lead to better outcomes. Recently, the American Association for the Study of Liver Diseases (AASLD) and European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) committees have made recommendations for the diagnosis and management of NAFLD in pediatric patients. This review focuses on current literature on epidemiology, natural history, pathogenesis along with summarizing the recent guidelines on diagnosis and treatment of pediatric NAFLD.

Keywords: Nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, children, epidemiology, natural history, diagnosis, management.

Purchase Online Rights and Permissions

Article Details

Volume: 10
Issue Number: 2
First Page: 151
Last Page: 161
Page Count: 11
DOI: 10.2174/157339631130900007
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science