Surfactant-Associated Proteins: Structure, Function and Clinical Implications

ISSN: 1875-6336 (Online)
ISSN: 1573-3963 (Print)

Volume 13, 4 Issues, 2017

Download PDF Flyer

Current Pediatric Reviews

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Giuseppe Buonocore
Department of Molecular and Developmental Medicine
University of Siena

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Surfactant-Associated Proteins: Structure, Function and Clinical Implications

Current Pediatric Reviews, 10(2): 162-167.

Author(s): Anastasia K. Ketko and Steven M Donn.

Affiliation: 8-621 C.S. Mott Children’s Hospital, 1540 E. Hospital Drive, Ann Arbor, MI 48109-5254, USA.


Surfactant replacement therapy is now the standard of care for infants with respiratory distress syndrome. As the understanding of surfactant structure and function has evolved, surfactant-associated proteins are now understood to be essential components of pulmonary surfactant. Their structural and functional diversity detail the complexity of their contributions to normal pulmonary physiology, and deficiency states result in significant pathology. Engineering synthetic surfactant protein constructs has been a major research focus for replacement therapies. This review highlights what is known about surfactant proteins and how this knowledge is pivotal for future advancements in treating respiratory distress syndrome as well as other pulmonary diseases characterized by surfactant deficiency or inactivation.


Deficiency, function, phospholipid, protein, pulmonary, structure, surfactant.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 10
Issue Number: 2
First Page: 162
Last Page: 167
Page Count: 6
DOI: 10.2174/157339631130900006
Price: $58
11th annual Paediatric Clinical Trials Conference

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science