Conventional Anticancer Therapeutics and Telomere Maintenance Mechanisms

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)

Volume 21, 42 Issues, 2015

Download PDF Flyer

Current Pharmaceutical Design

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 62nd of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

William A. Banks
Building 1, Room 810A
1600 S. Columbian Way
Seattle, WA 98108

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.452
5 - Year: 3.504

Conventional Anticancer Therapeutics and Telomere Maintenance Mechanisms

Current Pharmaceutical Design, 20(41): 6452-6465.

Author(s): Orit Uziel and Meir Lahav.

Affiliation: Department of Medicine A, Rabin Medical Center, Beilinson Campus, Petah-Tikva, ISRAEL, 49100.


The telomere-telomerase system has a unique role in the biology of cancer. Telomere maintenance, mostly affected by the up regulation of telomerase activity, is a prerequisite for perpetuation of malignant cells. This fundamental biologic feature defines telomere maintenance as an attractive therapeutic target for most types of cancer. This review summarizes some critical aspects of telomere biology with special emphasis on the connection to anticancer therapy. In particular, the effects on the telomere - telomerase system of conventional anticancer treatments, including various cytotoxic drugs, targeted biological agents and radiotherapy, and their possible combination with telomerase-directed therapy are discussed. Several potential problems, including side effects and complications inherent to perturbations of telomere biology in normal cells, are also highlighted. In spite of significant progress in this field, there are still several issues that have to be addressed and ultimately resolved in order to obtain a better characterization of the pros and cons of telomerasedirected therapies and, consequently, their clinical relevance.


Chemotherapy, telomeres, telomerase, radiotherapy.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 20
Issue Number: 41
First Page: 6452
Last Page: 6465
Page Count: 14
DOI: 10.2174/1381612820666140630100130

Related Journals

Webmaster Contact: Copyright © 2015 Bentham Science