Cell-Penetrating Peptides as Delivery Enhancers for Vaccine

ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)

Volume 16, 12 Issues, 2015

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Current Pharmaceutical Biotechnology

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Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth

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Cell-Penetrating Peptides as Delivery Enhancers for Vaccine

Author(s): Yuhong Jiang, Man Li, Zhirong Zhang, Tao Gong and Xun Sun

Affiliation: West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Road, Chengdu 610041, People's Republic of China.


The poor permeability of cellular membrane is one of the principal hurdles of most drug administrations including vaccine system, consequently impairing drug efficiency. In order to address this natural barrier, cell-penetrating peptides (CPPs) have been developed to facilitate molecular cargos to enter cells. CPPs, generally short peptides with 5-30 amino acids, can be classified in to cationic, amphipathic and hydrophobic types according to physical-chemical properties. In this review, different processes of antigen uptake, subsequent processing and presentation of CPP-based vaccine are comprehensively summarized despite precise mechanisms are not still established. Some experimental factors such as cell types, concentration of CPPs and antigenic cargos have been reported to affect antigen uptake orientation. Moreover, this review discusses different antigenic cargos where CPPs can transport for vaccine delivery as well as the application of CPPs in vaccine system via different administration routes like transdermal, subcutaneous and mucosal immunization.

Keywords: Administration route, antigenic cargo, cell-penetrating peptide, vaccine delivery.

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Article Details

Volume: 15
Issue Number: 3
First Page: 256
Last Page: 266
Page Count: 11
DOI: 10.2174/1389201015666140813130114
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