Dietary Polyphenols for Treatment of Alzheimer’s Disease– Future Research and Development

ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)

Volume 16, 12 Issues, 2015

Download PDF Flyer

Current Pharmaceutical Biotechnology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 112th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.511
5 - Year: 2.817

Dietary Polyphenols for Treatment of Alzheimer’s Disease– Future Research and Development

Author(s): D. Sheeja Malar and K. Pandima Devi

Affiliation: Department of Biotechnology, Alagappa University, Karaikudi-630 004, Tamil Nadu, India.


Polyphenols are the most abundant components of our daily food, occupying the major portion of naturally occurring phytochemicals in plants. Currently, polyphenols have received a special attention from the scientific community against health risk because of their antioxidant capacity and the ability to scavenge the free radicals formed during the pathological process like cancer, cardiovascular diseases and neurodegenerative disorders. Alzheimer’s disease, one of the common forms of dementia is an intricate, multifactorial mental illness which is characterized by age-dependent memory loss ultimately leading to a steady decline of cognitive function. Extracellular amyloid beta deposition and intracellular tau hyperphosphorylation are the two main alterations occurring in the cells reported to cause neuronal dysfunction during AD. Dietary intake of polyphenols is known to attenuate the progression of the disease by showing strong potential to tackle the alterations and reduce the risk of AD by reversing the cognitive deficits. A large number of polyphenolic compounds showing promising results against AD pathologies have been identified and described in the past decade. Many efforts have been made to unravel the molecular mechanisms and the specific interactions of polyphenols with their targets in the pathway. This review focuses on the therapeutic potential and promising role of dietary polyphenols as nutraceuticals to combat AD.

Keywords: Acetylcholine, Alzheimer's disease, amyloid beta, beta secretase, neurofibrillary tangles, neuroinflammation, polyphenols, sirtuins.

Purchase Online Order Reprints Order Eprints Rights and Permissions


Article Details

Volume: 15
Issue Number: 4
First Page: 330
Last Page: 342
Page Count: 13
DOI: 10.2174/1389201015666140813122703
ADC Summit 2015

Related Journals

Webmaster Contact: Copyright © 2015 Bentham Science