Resveratrol as a Gene Regulator in the Vasculature

ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)


Volume 15, 12 Issues, 2014


Download PDF Flyer




Current Pharmaceutical Biotechnology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 112th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth
Germany


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.511
5 - Year: 2.817

Resveratrol as a Gene Regulator in the Vasculature

Author(s): Ning Xia, Ulrich Forstermann and Huige Li

Affiliation: Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Obere Zahlbacher Str. 67, 55131 Mainz, Germany.

Abstract

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) possesses multiple protective properties in the vasculature, including anti-oxidative and anti-inflammatory effects and improvement of endothelial function. A substantial part of these effects is attributable to gene expression changes induced by the compound. Resveratrol can activate the NAD-dependent deacetylase sirtuin 1 (SIRT1), leading to deacetylation of SIRT1 target molecules such as NF-kB and forkhead box O (FOXO) transcription factors. The inhibition of NF-kB by resveratrol reduces the expression of inflammation mediators. FOXO factors are implicated in the upregulation of antioxidant enzymes and the endothelial-type nitric oxide synthase. In addition, resveratrol upregulates a number of antioxidant enzymes by activating nuclear factor-E2-related factor-2 (Nrf2) and downregulates NADPH oxidases through yet known mechanisms.

Keywords: Gene regulation, nitric oxide, oxidative stress, resveratrol, vascular inflammation.

Download Free Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 15
Issue Number: 4
First Page: 401
Last Page: 408
Page Count: 8
DOI: 10.2174/1389201015666140711114450
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science