Progress in Development of Group A Streptococcus Vaccines

ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)


Volume 15, 12 Issues, 2014


Download PDF Flyer




Current Pharmaceutical Biotechnology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 112th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth
Germany


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.511
5 - Year: 2.817

Progress in Development of Group A Streptococcus Vaccines

Author(s): Yingli Song, Xiaolan Zhang, Chunmei Lu, Fengmin Zhang and Hui Zhu

Affiliation: Department of Physiology, Harbin Medical University, Harbin 150081, China

Abstract

Streptococcus pyogenes or Group A Streptococcus (GAS) is a major Gram-positive human pathogen that causes diverse human diseases with a high morbidity and mortality worldwide. The development of an effective GAS vaccine is hindered by the occurrence of many unique GAS serotypes, the complexity of the global epidemiology of GAS infections, and safety concerns over the cross-reactivity of some antigen-specific antibodies with human tissues and proteins. Although no licensed GAS vaccine is available, a number of candidate vaccines have been or are being evaluated in laboratory or in clinical trials. This minireview provides brief information on the progress and difficulty in the development of GAS vaccines.

Keywords: Arginine deiminase, Group A Streptococcus, Group A carbohydrate, M protein, ScpA, Shr, SpyCEP, SsE, Streptococcal fibronectin-binding proteins, Streptococcal pyrogenic exotoxins, Trigger factor, Vaccine.

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 14
Issue Number: 11
First Page: 947
Last Page: 950
Page Count: 4
DOI: 10.2174/1389201014666131226125540
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science