Influence of Physical Immobilization of dsDNA on Carbon Based Matrices of Electrochemical Sensors

ISSN: 1875-676X (Online)
ISSN: 1573-4129 (Print)

Volume 13, 6 Issues, 2017

Download PDF Flyer

Current Pharmaceutical Analysis

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Anastasios Economou
Department of Chemistry
Laboratory of Analytical Chemistry
University of Athens

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 0.885
5 - Year: 0.647

Influence of Physical Immobilization of dsDNA on Carbon Based Matrices of Electrochemical Sensors

Current Pharmaceutical Analysis, 10(1): 20-29.

Author(s): Livia Alexandra Gugoasa, Raluca-Ioana Stefan-van Staden, Anton Alexandru Ciucu and Jacobus Frederick van Staden.

Affiliation: Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Street, 060021 Bucharest, Romania.


The influence of addition of dsDNA on the electrocatalytic effect of carbon matrices, e.g. synthetic monocrystalline diamond, fullerenes C60 and multi-walled carbon nanotubes was studied. Three neurotransmitters: dopamine, epinephrine and norepinephrine, which are known as biomarkers that play an important role in transporting and modulating nervous impulses in the synapse were chosen as model analytes. Cyclic voltammetry was used to determine the optimum working conditions with a phosphate buffer solution at a pH=4 with KNO3 as support electrolyte. Differential pulse voltammograms (DPVs) were employed to assess the electrolytic effect of dsDNA on carbon matrices under the optimized conditions, and the potential applications of the biosensors for pharmaceutical and biomedical analysis.


dsDNA, sensors, carbon based matrices, neurotransmitters.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 10
Issue Number: 1
First Page: 20
Last Page: 29
Page Count: 10
DOI: 10.2174/157341291001140102104740

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science