Bromide-bromate Couple of Varying Ratios for Bromination, Vicinal Functionalisation and Oxidation in a Clean Manner

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)


Volume 11, 6 Issues, 2014


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Universidad Nacional de La Plata
Buenos Aires
Argentina


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Bromide-bromate Couple of Varying Ratios for Bromination, Vicinal Functionalisation and Oxidation in a Clean Manner

Author(s): Subbarayappa Adimurthy, Brindaban C. Ranu, Gadde Ramachandraiah, Bishwajit Ganguly and Pushpito K. Ghosh

Affiliation: Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Bhavnagar - 364 002, Gujarat, India.

Abstract

The review highlights applications of bromide-bromate couple in organic synthesis. The couple having 5:1 mole ratio of bromide to bromate is useful for preparation of dibromo derivatives from alkenes/alkynes. The 2:1 couple affects substitution with high bromine atom efficiency. Vicinal functionalization of olefins has also been studied. The 1:8 bromide-bromate couple has proved promising in several oxidation reactions, the performance exceeding that of bromate alone. This reagent was also the most effective for deiodination of styrene-based iodohydrins with concomitant rearrangement by a novel pathway. In all the cases the reagents were activated through in situ acidification. The 5:1 reagent is obtained as intermediate during liquid bromine manufacture and the other reagents were prepared from it using ClO-. Liquid bromine could be avoided in the product life cycle.

Keywords: Bromide-bromate couples, direct preparation from bromine intermediate, In situ activation, reagents for green bromination and oxidation, regeneration and reuse.

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Article Details

Volume: 10
Issue Number: 6
First Page: 864
Last Page: 884
Page Count: 21
DOI: 10.2174/157017941006140206102818
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