Smiles Rearrangement in Synthetic Chemistry

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)


Volume 11, 6 Issues, 2014


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Prof. Eduardo A Castro
Universidad Nacional de La Plata
Buenos Aires
Argentina


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Smiles Rearrangement in Synthetic Chemistry

Author(s): Shuai Xia, Li-Ying Wang, Hua Zuo and Zhu-Bo Li

Affiliation: College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.

Abstract

Smiles rearrangement, an organic intramolecular nucleophilic aromatic substitution reaction, provides a powerful access to the synthesis of a variety of heterocyclic compounds. In contrast with the conventional protocols for the preparation of complex molecular structures, Smiles rearrangement, through the conversion of an easily-synthesized precursor into a desired “difficult-to-make’’ product, presents to be an extremely useful tool in organic synthesis. In the reactions, the yields of the Smiles rearrangement are profoundly influenced by electronic effect, steric effect and even the pH value. In this review, the detailed preparations of numerous molecules by taking advantage of Smiles rearrangement are discussed.

Keywords: Electronic effect, heterocycles, Meisenheimer complex, nucleophilic substitution, organic synthesis, steric effect, Smile rearrangement.

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Article Details

Volume: 10
Issue Number: 6
First Page: 935
Last Page: 946
Page Count: 12
DOI: 10.2174/15701794113106660081
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