Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)


Volume 12, 6 Issues, 2015


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Current Organic Synthesis

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Eduardo A. Castro
Universidad Nacional de La Plata
Buenos Aires
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Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives



Current Organic Synthesis, 11(2): 310-316.

Author(s): Wang Liju and Keyume Ablajan.

Affiliation: Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, P.R. China.

Abstract

Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol under reflux conditions led to excellent yields of 79%-94%.




Keywords:

Dihydropyrano[2, 3-c]pyrazole, multi-component reactions, one-pot synthesis, Pyrrolidine, Triazolo[4, 3-a]pyrimidines.



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Article Details

Volume: 11
Issue Number: 2
First Page: 310
Last Page: 316
Page Count: 7
DOI: 10.2174/15701794113106660079
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