Inhibitors of Catechol-O-methyltransferase in the Treatment of Neurological Disorders

ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)


Volume 14, 2 Issues, 2014


Download PDF Flyer




Central Nervous System Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Gregory S. Hamilton
Eisai Inc.
Baltimore, MD
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Inhibitors of Catechol-O-methyltransferase in the Treatment of Neurological Disorders

Author(s): Nidhi Jatana, N. Apoorva, Sonika Malik, Aditya Sharma and Narayanan Latha

Affiliation: Bioinformatics Infrastructure Facility, Sri Venkateswara College, University of Delhi, Benito Juarez Road, Dhaula Kuan, New Delhi 110021, India.

Abstract

Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. COMT has implications in many neurological and psychiatric disorders like schizophrenia, Parkinson’s disease (PD), bipolar disorders, etc. and therefore, it serves as an important drug target. Since its characterization in 1957, many inhibitors were designed where the first generation inhibitors were found to be highly toxic, short acting and had poor bioavailability. Currently, two of the second generation inhibitors, tolcapone and entacapone have been used for treatment of PD but are associated with various dopaminergic and gastro-intestinal side-effects. There have been several approaches for the design of novel COMT inhibitors with a good and safe therapeutic profile. The focus of this article is to review the current knowledge on COMT and the role of COMT inhibitors in the treatment of neurological disorders. The inhibitors have been classified into six different classes based on the structural framework. A historical overview of the discovery and development of COMT inhibitors is presented with a special emphasis on new generation of inhibitors till date.

Keywords: Catechol-O-methyltransferase (COMT), COMT isoforms, V108M polymorphism, structure of COMT, COMTInhibitors, classification of COMT-inhibitors.

Download Free Rights and Permissions

  
  



Article Details

Volume: 13
Issue Number: 3
First Page: 166
Last Page: 194
Page Count: 29
DOI: 10.2174/1871524913666140109113341
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science