Semicarbazone Analogs as Anticonvulsant Agents: A Review

ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)


Volume 14, 2 Issues, 2014


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Central Nervous System Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Gregory S. Hamilton
Eisai Inc.
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Semicarbazone Analogs as Anticonvulsant Agents: A Review

Author(s): Mohamed Jawed Ahsan

Affiliation: Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan 302 023, India.

Abstract

Semicarbazones are synthesized by the condensation of semicarbazide and aldehyde/ketone. The literature survey revealed that semicarbazones had been emerged as compounds with diverse biological activities including anticonvulsant, antitubercular, anticancer, and antimicrobial activities. The anticonvulsant activity of semicarbazones is mainly attributed due to the presence of an aryl binding site with aryl/alkyl hydrophobic group, a hydrogen bonding domain and an electron donor group and they are suggested to act by inhibiting sodium ion (Na+) channel. Dimmock et al., reported an extensive series of semicarbazones and reported 4-(4-fluorophenoxy) benzaldehyde semicarbazone (C0102862, V102862) as lead molecule. In MES (oral) screening C0102862 showed protective index (PI > 315) more than carbamazepine (PI 101), phenytoin (PI > 21.6) and valproate (PI > 2.17). This review briefly describes the information available about semicarbazone analogs and their anticonvulsant activity.

Keywords: Anticonvulsant Agents, Binding site theory, Na+ channel blocker, Pharmacophore model, Review, Semicarbazones.

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Article Details

Volume: 13
Issue Number: 2
First Page: 148
Last Page: 158
Page Count: 11
DOI: 10.2174/18715249113136660016
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