Psychomotor Seizure Test, Neurotoxicity and in vitro Neuroprotection Assay of some Semicarbazone Analogues

ISSN: 1875-6166 (Online)
ISSN: 1871-5249 (Print)


Volume 14, 2 Issues, 2014


Download PDF Flyer




Central Nervous System Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Gregory. S. Hamilton
Intellectual Property Dept. Eisai Inc.
6611 Tributary Street
Baltimore, MD 21224
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Psychomotor Seizure Test, Neurotoxicity and in vitro Neuroprotection Assay of some Semicarbazone Analogues

Author(s): Mohamed Jawed Ahsan and James P. Stables

Affiliation: Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan 302 023, India.

Abstract

In continuance of our search for anticonvulsant agents, we reported herein the synthesis, characterization and anticonvulsant evaluation of some newer semicarbazone analogues. A few compounds were also screened for neuroprotection assay. Some of the compounds showed significant anticonvulsant activity. Compound 4a showed 25% (1/4, 0.25 h), 75% (3/4, 0.5 & 2.0 h) and 100% (4/4, 1.0 h) protection against 6 Hz psychomotor seizure test at 100 mg/kg devoid of any neurotoxicity. Compound 4d showed neuroprotection activity with 26.3 ± 2.3 percent of total propidium iodide uptake at 100 μ M and IC50 of the compound was calculated using dose response curve by probit analysis and was found to be 149 ± 1.22 μ M.

Keywords: Anticonvulsant agents, 6 Hz psychomotor seizure test, Maximal electroshock seizure, Neurotoxicity, Semicarbazones.

Purchase Online Rights and Permissions

Article Details

Volume: 13
Issue Number: 2
First Page: 141
Last Page: 147
Page Count: 7
DOI: 10.2174/18715249113139990014
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science