Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala

ISSN: 1875-6190 (Online)
ISSN: 1570-159X (Print)


Volume 12, 6 Issues, 2014


Download PDF Flyer




Current Neuropharmacology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 149th of 261 in Pharmacology & Pharmacy
  • 176th of 252 in Neurosciences

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
T.E. Salt
University College London
Institute of Ophthalmology
London EC1V 9EL
UK


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.031
5 - Year: 3.084

Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala

Author(s): George Anderson and Michael Maes

Affiliation: George Anderson, CRC, Rm 30, 57 Laurel St. Glasgow G11 7QT, Scotland, UK.

Abstract

The autistic spectrum disorders (ASD) form a set of multi-faceted disorders with significant genetic, epigenetic and environmental determinants. Oxidative and nitrosative stress (O&NS), immuno-inflammatory pathways, mitochondrial dysfunction and dysregulation of the tryptophan catabolite (TRYCATs) pathway play significant interactive roles in driving the early developmental etiology and course of ASD. O&NS interactions with immunoinflammatory pathways mediate their effects centrally via the regulation of astrocyte and microglia responses, including regional variations in TRYCATs produced. Here we review the nature of these interactions and propose an early developmental model whereby different ASD genetic susceptibilities interact with environmental and epigenetic processes, resulting in glia biasing the patterning of central interarea interactions. A role for decreased local melatonin and N-acetylserotonin production by immune and glia cells may be a significant treatment target.

Keywords: Autism, Oxidative stress, Nitrosative stress, glia, Immuno-inflammation, tryptophan, melatonin.

Purchase Online Rights and Permissions

Article Details

Volume: 12
Issue Number: 2
First Page: 148
Last Page: 167
Page Count: 20
DOI: 10.2174/1570159X11666131120223757
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science