Therapeutical Potential of CB<sub>2</sub> Receptors in Immune-Related Diseases

ISSN: 1874-4702 (Online)
ISSN: 1874-4672 (Print)

Volume 10, 4 Issues, 2017

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Current Molecular Pharmacology

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Michael Kahn
University of Southern California
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Los Angeles, NRT 4501, CA 90033

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Therapeutical Potential of CB2 Receptors in Immune-Related Diseases

Current Molecular Pharmacology, 6(3): 183-203.

Author(s): Natascha Leleu-Chavain, Pierre Desreumaux, Philippe Chavatte and Regis Millet.

Affiliation: Universite du Droit et de la Sante de Lille, EA 4481, Institut de Chimie Pharmaceutique Albert Lespagnol, 3 rue du Pr. Laguesse, B.P. 83, F-59006 Lille, France.


The cannabinoid receptor CB2 is highly expressed in immune cells suggesting an important role in numerous diseases such as inflammation, cancer, osteoporosis and liver diseases relating to modulation of the immune system. As a consequence, activation of receptor CB2 is a promising therapeutic strategy for the treatment of a large range of diseases. Indeed, selective CB2 agonists display beneficial anti-inflammatory, anti-cancer and antifibrogenic properties and positive effects on liver disease and osteoporosis. This article reviews the CB2 involvement in the immune system and the promising therapeutical potential of selective CB2 agonists in the treatment of several immune-related diseases.


Analgesic, anticancer, antifibrogenic, anti-inflammatory, cannabinoid receptors, CB<sub>2</sub> agonists, immune system, immune-related diseases, liver disease, osteoporosis.

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Article Details

Volume: 6
Issue Number: 3
First Page: 183
Last Page: 203
Page Count: 21
DOI: 10.2174/1874467207666140219122337
Price: $58
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