miR-143: A Novel Regulator of MyoD Expression in Fast and Slow Muscles of Siniperca chuatsi

ISSN: 1875-5666 (Online)
ISSN: 1566-5240 (Print)

Volume 16, 10 Issues, 2016

Download PDF Flyer

Current Molecular Medicine

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 47th of 124 in Medicine, Research & Experimental

Submit Abstracts Online Submit Manuscripts Online

David W. Li
College of Medicine
University of Nebraska Medical Center
Omaha, NE

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.912
5 - Year: 3.478

miR-143: A Novel Regulator of MyoD Expression in Fast and Slow Muscles of Siniperca chuatsi

Current Molecular Medicine, 14(3): 370-375.

Author(s): L. Chen, P. Wu, X.-H. Guo, Y. Hu, Y.-L. Li, J. Shi, K.-Z. Wang, W.-Y. Chu and J-S Zhang.

Affiliation: Department of Bioengineering and Environmental Science, Changsha University, Changsha, Hunan 410003, China.


The fast and slow skeletal muscle fibers in fish are separated to a much greater degree than in mammals. MyoD is required for the maintenance of normal fiber type balance in muscles. So far, the upstream regulatory factors of MyoD in terms of controlling muscle phenotype are poorly understood. In the present study, we used Siniperca chuatsi as a model system and demonstrated that miR-143 expression was negatively correlated with MyoD expression in the fast and slow muscles of S. chuatsi. The luciferase reporter assay further verified the direct interaction between the miR-143 and MyoD. The miR-143 suppression also led to the significant increase in MyoD and fast myosin heavy chain gene expression in vivo. Taken together, our studies indicated that miRNA participates in controlling the performance of different muscle fiber types in vertebrates.


microRNA, muscle fiber, MyoD, regulation, Siniperca chuatsi.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 14
Issue Number: 3
First Page: 370
Last Page: 375
Page Count: 6
DOI: 10.2174/1566524014666140228100250
Price: $58
2016 World Biology and Genetics Congress

Related Journals

Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science