Focus on Microwaves Assisted Halogen-halogen Exchange Reaction Conditions on 2-Halopyridines

ISSN: 2213-3364 (Online)
ISSN: 2213-3356 (Print)

Volume 4, 4 Issues, 2017

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Current Microwave Chemistry

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Bimal K. Banik
Vice President of Research & Education Development
Community Health Systems of South Texas (CHSST)
Edinburg, TX

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Focus on Microwaves Assisted Halogen-halogen Exchange Reaction Conditions on 2-Halopyridines

Current Microwave Chemistry, 1(1): 75-80.

Author(s): Serge Perato, Marcella De Giorgi, Gregory Burzicki, Florent Legalite, Sylvain Rault and Anne Sophie Voisin-Chiret.

Affiliation: 1-Normandie Univ, France; 2-UNICAEN, CERMN (Centre d’Etudes et de Recherche sur le Medicament de Normandie Upres EA 4258-FR CNRS 3038 INC3M, Bd Becquerel), F-14032 Caen, France.


This paper describes an optimised microwave irradiation methodology on various substituted pyridines in order to realise a halogen-halogen exchange. This protocol provides an efficient and simple methodology to improve the reactivity of some positions on the pyridine ring towards metallocatalysed reactions. Influence of various substituents has been explored and limiting factors of reaction have been highlighted.


Acetyl chloride, 2, 3-dihalopyridine, 2, 4-dihalopyridine, 2, 6-diahlopyridine, 2-halopyridine, halogen exchange, regioselectivity, microwaves, sodium iodide, suzuki-Miyaura cross-coupling reaction.

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Article Details

Volume: 1
Issue Number: 1
First Page: 75
Last Page: 80
Page Count: 6
DOI: 10.2174/22133356114019990003
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