Correlation between Changes of FDG-PET findings and those of Mini-Mental Status Examination Scores in Patients with Moderate Alzheimer’s Disease: Usefulness of Stereotactic Extraction Estimation

ISSN: 2211-5544 (Online)
ISSN: 2211-5552 (Print)


Volume 3, 3 Issues, 2014


Download PDF Flyer




Current Molecular Imaging

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Abass Alavi
Department of Radiology/Nuclear Medicine
Hospital of the University of Pennsylvania
Philadelphia, PA
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Correlation between Changes of FDG-PET findings and those of Mini-Mental Status Examination Scores in Patients with Moderate Alzheimer’s Disease: Usefulness of Stereotactic Extraction Estimation

Author(s): Nobuhiko Miyazawa

Affiliation: Department of PET Center, Kofu Neurosurgical Hospital, Kofu, Yamanashi, Japan.

Abstract

Purpose: To investigate the association between changes on [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and clinical deterioration in patients with moderate Alzheimer’s disease (AD), findings of FDG-PET in the first and follow-up stages were compared using stereotactic extraction estimation (SEE) and three-dimensional stereotactic surface projection (3D-SSP).

Methods and patients: Thirty consecutive patients with AD examined twice by FDG-PET were divided into two groups with improved or stable mini-mental state examination (MMSE) (SI group, 14 patients) and deteriorated MMSE (D group, 16 patients). Statistical analysis using SEE in 3D-SSP was used to investigate the changes in Z-score in the frontal, parietal, temporal, and occipital lobes, precuneus, and posterior cingulate cortex (PCC).

Results: Changes in Z-scores in the PCC (p=0.0006) and temporal lobe (p=0.021) were significantly higher in the D group than in the SI group. Z-score was significantly higher in the left PCC compared to the right PCC (p=0.0097).

Conclusions: SEE in 3D-SSP is the helpful method to detect the regional differences. Metabolic reduction on FDG-PET in the left PCC detected by SEE and 3D-SSP is associated with clinical deterioration in patients with moderate AD.


Keywords: Alzheimer’s disease, FDG-PET, Stereotactic extraction estimation, 3D-SSP

Purchase Online Rights and Permissions

Article Details

Volume: 3
First Page: 1
Last Page: 5
Page Count: 5
DOI: 10.2174/2211555203666140423225138
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science