Nutritional Iron Deficiency: the Role of Oral Iron Supplementation

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 21, 38 Issues, 2014


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Current Medicinal Chemistry

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Nutritional Iron Deficiency: the Role of Oral Iron Supplementation

Author(s): Joanna I. Lachowicz, Valeria M. Nurchi, Daniela Fanni, Clara Gerosa, Massimiliano Peana and Maria A. Zoroddu

Affiliation: Dipartimento di Scienze Chimiche e Geologiche, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato, Italy

Abstract

Nutritional iron deficiency represents a relevant health problem mainly in developing countries. Children and pregnant women represent the main target of this disease, and the low amount of bio-available iron mostly depends on plant-based diets. Iron deficiency may have serious consequences, with severe impairment of the immune function leading to infectious diseases. The brain development in embryos and fetuses during gestation can be greatly affected by iron deficiency of the mother with heavy outcomes on the cognition status of children. A better understanding of molecular pathways involved in iron absorption and metabolism should be considered as the basis for new strategies for developing a molecular therapy for iron deficiency. Different therapeutic strategies are here summarized, and iron fortification appears as the best tool

Keywords: Iron absorption, iron deficiency, iron fortified food, iron metabolism, iron supplement

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Article Details

Volume: 21
First Page: 1
Last Page: 11
Page Count: 11
DOI: 10.2174/0929867321666140706143925
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