Physiopathological Roles of P2X Receptors in the Central Nervous System

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 22, 38 Issues, 2015


Download PDF Flyer




Current Medicinal Chemistry

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 6th of 59 in Chemistry & Medicinal
  • 47th of 254 in Pharmacology & Pharmacy
  • 81st of 289 in Biochemistry & Molecular Biology

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.853
5 - Year: 4.115

Select Language (选择语言):

Physiopathological Roles of P2X Receptors in the Central Nervous System

Author(s): G. Burnstock

Affiliation: University College Medical School, United Kingdom.

Abstract

Potent actions of ATP in the central nervous system (CNS) were reported in the late 1940’s, but cloning and characterisation of receptors for purines and pyrimidines did not take place until the early 1990’s, which identified seven P2X ion channel receptor subtypes, three of which form the cation channel as homomultimers or heteromultimers. P2X receptor subtypes are widely expressed in the CNS and their distribution is described in different regions. They function in synaptic cotransmission and neuromodulation, as well as in trophic signalling. ATP released from nerves and astroglial cells are predominantly involved in neuron-glial interactions. Purinergic signalling is involved in normal behaviour, including learning and memory, sleep and arousal, locomotor and feeding activities and cognition. P2X receptors participate in CNS pathophysiology, including injury, inflammation, Alzheimer’s and Parkinson’s diseases, multiple sclerosis and amyotrophic lateral sclerosis, depression and anxiety. P2X4 and P2X7 receptor antagonists are effective via microglia against neuropathic pain, while P2X3 receptor antagonists also reduce neuropathic pain, but via a differernt mechanism.

Keywords: ATP, brain stem, glia, glutamate, hippocampus, memory, neurodegenerative diseases, neuropathic pain, neuroprotection, spinal cord.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 22
Issue Number: 7
First Page: 819
Last Page: 844
Page Count: 26
DOI: 10.2174/0929867321666140706130415
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2015 Bentham Science