Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 21, 38 Issues, 2014


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Current Medicinal Chemistry

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  • 9th of 58 in Chemistry & Medicinal
  • 49th of 254 in Pharmacology & Pharmacy
  • 96th of 291 in Biochemistry & Molecular Biology

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


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Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress

Author(s): H. Fu, H. Fang, Jie Sun, H. Wang, A. Liu, J. Sun and Z. Wu

Affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, 18877 Jingshi Rd., Ji’nan, Shandong 250062, China.

Abstract

Since Bortezomib was approved by US FDA as the first drug to treat multiple myeloma, various boronic acid compounds have been developed as enzyme inhibitors. This paper reviewed the progress of boronic acid-based inhibitors against enzymes including proteasome, serine protease, HDACs and other enzymes in the past decade.

Keywords: Boronic acid, bortezomib, enzyme inhibitor, HDACs, proteasome inhibitor, serine protease.

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Article Details

Volume: 21
Issue Number: 28
First Page: 3271
Last Page: 3280
Page Count: 10
DOI: 10.2174/0929867321666140601200803
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