Delivery of Therapeutics and Molecules Using Self-Assembled Peptides

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 21, 38 Issues, 2014


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Current Medicinal Chemistry

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  • 49th of 254 in Pharmacology & Pharmacy
  • 96th of 291 in Biochemistry & Molecular Biology

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
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Delivery of Therapeutics and Molecules Using Self-Assembled Peptides

Author(s): S. Sundar, Y. Chen and Y.W. Tong

Affiliation: 4 Engineering Drive 4, Singapore 117576.

Abstract

The use of nanobiotechnology in the formulation of drug carriers has been gaining popularity in recent years. Peptide self-assembly technology is a particularly attractive option due to its simplicity and programmability. Selfassembling peptide amphiphiles are surfactant-like molecules that are capable of spontaneous organization into a variety of nanostructures. The structural and functional features of these nanostructures can be designed through alterations to the peptide sequence. With a keen understanding of the supramolecular principles governing the non-covalent interactions involved, drug loading strategies can be customised. Hydrophobic drugs can be hidden within the core via aromatic interactions while gene-based therapeutics can be complexed with a cationic region of lysine residues. This review article focuses on the application of self-assembling peptide amphiphiles to drug delivery in the area of anti-cancer therapeutics, protein- and peptide-based therapeutics and nucleic acid-based therapeutics. Specific examples are used to discuss the various systems available and emphasis is given to the encapsulation and release mechanism.

Keywords: Anti-Cancer, drug delivery, growth factors, hormones, nanomedicine, nucleic acids, peptide amphiphiles, proteins, self-assembly, therapeutics.

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Article Details

Volume: 21
Issue Number: 22
First Page: 2469
Last Page: 2479
Page Count: 11
DOI: 10.2174/0929867321666131212152637
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