Biological Interfacial Engineering for Metastatic Cancer Diagnosis and Intervention

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)

Volume 24, 42 Issues, 2017

Download PDF Flyer

Current Medicinal Chemistry

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 10th of 59 in Chemistry & Medicinal
  • 63rd of 253 in Pharmacology & Pharmacy
  • 100th of 289 in Biochemistry & Molecular Biology

Submit Abstracts Online Submit Manuscripts Online

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.455
5 - Year: 3.792

Biological Interfacial Engineering for Metastatic Cancer Diagnosis and Intervention

Current Medicinal Chemistry, 21(22): 2510-2521.

Author(s): B. Wang, H. Zhou, Y. Luo, R. Tang and S Zheng.

Affiliation: Key Laboratory of Cancer Prevention and Intervention of Ministry of Education, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.


Metastasis is responsible for most deaths of cancer burdens. Given that metastatic cancer cells are generally very low in quantity but high in multiplicity, and able to migrate to diverse organs, the diagnosis and intervention of metastatic cancers face varieties of challenges. For example, the biomarker for early diagnosis, and detection of circulating tumor cells by way of epithelial cell adhesion molecule, are complicated by the epithelial-mesenchymal-transition (EMT). Enhanced permeation and retention have been widely explored but with limitations, especially for microscale metastatic tumors. Furthermore, drug-resistance and side-effects of chemotherapy remain problematic for diverse cancers. Interfaces of cells play essential roles in many physiological activities including signal transduction and immunological recognition, which can be exploited for medical application of interfacial materials; indeed, given unique chemical and physical interfacial properties, numerous micro/nano particles and interfacial materials exhibit great potentials for diagnosis and intervention of metastatic cancers. Here we highlight current research, opportunities and challenges for application potentials of biological interfacial engineering in diagnosis and intervention of metastatic cancers.


Biological interfacial engineering, cancer, cancer diagnosis and intervention, metastasis.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 21
Issue Number: 22
First Page: 2510
Last Page: 2521
Page Count: 12
DOI: 10.2174/0929867321666131213102724
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science