The Brain-Immune-Gut Triangle: Innate Immunity in Psychiatric and Neurological Disorders

ISSN: 1875-631X (Online)
ISSN: 1573-3955 (Print)


Volume 10, 2 Issues, 2014


Download PDF Flyer




Current Immunology Reviews

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Cecil Czerkinsky
Institut de Pharmacologie Moleculaire et Cellulaire
UMR 7275 CNRS-INSERM-UNISA
660 Route des Lucioles
Valbonne, 06560
France


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


The Brain-Immune-Gut Triangle: Innate Immunity in Psychiatric and Neurological Disorders

Author(s): Attila Szabo and Eva Rajnavolgyi

Affiliation: Department of Immunology, Medical and Health Science Center, Faculty of Medicine, University of Debrecen, 98. Nagyerdei Blvd., Debrecen H-4012, Hungary.

Abstract

The communication between the immune and central nervous systems has been known for decades. Although the biological rules and complexity of the neuroimmune axis is yet to be clarified, in the modern era of immunology and clinical neurosciences it has become a dynamically evolving paradigm. In this review we trace the major findings of this emerging field with a special focus on innate immune cells and their phylogenetically conserved receptors, in line with their role in various psychiatric and neurological diseases. A particular interest will be given to monocytes, macrophages/microglia, dendritic cells, Toll-like and RIG-I-like receptors as well as their contribution to inflammation and other pathological processes in the CNS. Uncovering immunological mechanisms in the context of brain functions emerges as a promising avenue for future therapeutic interventions in various, still incurable ailments such as Alzheimer’s disease, schizophrenia, or different mood disorders such as major depression or bipolar disorder. We propose new perspectives for the pharmacological modification of innate immune cells and their response to inflammatory cues in the brain. A holistic concept of studying the gut-brain-immune triangle is also suggested to bring up novel approaches in immunology, gastroenterology, psychiatry and neurology.

Keywords: Gut microbiota, gut-brain axis, innate immunity, neuroimmunology, pattern recognition receptors, psychoneuroimmunology.

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 9
Issue Number: 4
First Page: 241
Last Page: 248
Page Count: 8
DOI: 10.2174/1573395509666131203225659
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science