Vasospastic Angina and Ca Channel Blockers

ISSN: 1875-6506 (Online)
ISSN: 1573-4021 (Print)

Volume 11, 2 Issues, 2015

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Current Hypertension Reviews

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Prof. Kazuomi Kario
Jichi Medical University
School of Medicine

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Vasospastic Angina and Ca Channel Blockers

Current Hypertension Reviews, 9(3): 219-223.

Author(s): Shinya Minatoguchi.

Affiliation: Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1-1, Gifu, Gifu 501-1194, Japan.


Coronary artery spasm is one of the causes of angina pectoris,acute myocardial infarction and ventricular fibrillation-related sudden death. It has been established that Ca channel blockers are protective against vasospastic angina (VSA) and treatment with Ca channel blockers provides a better prognosis of VSA. However, it is not still clarified what kinds of Ca channel blockers shows the best prognosis of VSA. We performed a meta-analysis in which 4Ca channel blockers amlodipine, nifedipine, benidipine and diltiazem were used for the treatment of VSA patients and found that among 4 Ca channel blockers, benidipine showed a statistically significant better prognostic effect on MACE than amlodipine, nifedipine or diltiazem.


Ca channel blocker, cardiovascular event, vasospastic angina.

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Article Details

Volume: 9
Issue Number: 3
First Page: 219
Last Page: 223
Page Count: 5
DOI: 10.2174/1573402110666140131161338

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