Detection of Cryptococcus neoformans Capsular Antigen in HIV-Infected Patients in the State of Para in the North of Brazil

ISSN: 1873-4251 (Online)
ISSN: 1570-162X (Print)


Volume 12, 6 Issues, 2014


Download PDF Flyer




Current HIV Research

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 23rd of 34 in Virology
  • 48th of 70 in Infectious Diseases
  • 102th of 137 in Immunology

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Charles Wood
University of Nebraska
Lincoln, NE
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.033
5 - Year: 1.941

Detection of Cryptococcus neoformans Capsular Antigen in HIV-Infected Patients in the State of Para in the North of Brazil

Author(s): Maurimelia M. da Costa, Lucimar di Paula Madeira, Rosimar N.M. Feitosa, Marluísa de Oliveira G. Ishak, Ricardo Ishak, Silvia H.M. da Silva and Antonio C.R. Vallinoto

Affiliation: Universidade Federal do Para, Instituto de Ciencias Biologicas, Laboratorio de Virologia, Rua Augusto Correa no. 1, 66.075-910, Belem, Para, Brazil.

Abstract

Cryptococcus neoformans is an important cause of morbidity in HIV-infected patients worldwide. In the northern region of Brazil, the prevalence of this infection is poorly known due to a lack of systematic investigations. This study aimed to determine the occurrence of cryptococcosis by detecting antigenaemia in HIV-infected patients in the State of Pará, Brazil. A latex Cryptococcus antigen detection kit was used to test 418 serum samples from HIV-infected patients seen at two Infectious Disease Specialized Units in the State of Pará. The C. neoformans antigenaemia prevalence was 2.6%, and titres reached 1:8. The cases occurred mainly in asymptomatic females, and 45% presented CD4+ T lymphocyte counts of fewer than 200 cells/mm3. These results show the importance of early C. neoformans antigenaemia detection to prevent fungal disease.

Keywords: Cryptococcus neoformans, HIV-1/AIDS, latex agglutination test.

Download Free Rights and Permissions

Article Details

Volume: 11
Issue Number: 8
First Page: 647
Last Page: 651
Page Count: 5
DOI: 10.2174/1570162X12666140311125420
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science