HIV-1 Rev Multimerization: Mechanism and Insights

ISSN: 1873-4251 (Online)
ISSN: 1570-162X (Print)


Volume 12, 6 Issues, 2014


Download PDF Flyer




Current HIV Research

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Charles Wood
University of Nebraska
Lincoln, NE
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.135
5 - Year: 1.856

HIV-1 Rev Multimerization: Mechanism and Insights

Author(s): Thomas Vercruysse and Dirk Daelemans

Affiliation: Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

Abstract

To export intron-containing viral mRNAs that encode the structural components of new viral particles from the nucleus to the cytoplasm, HIV-1 uses the cellular CRM1 export pathway that is exploited by the viral Rev protein. Rev multimerizes on the Rev response element (RRE) present in the intron-containing RNA species to bridge these to the cellular export factor CRM1. As a result, this Rev-RRE complex is exported to the cytoplasm. This review provides a systematic overview of different aspects of the crucial function of Rev multimerization, such as co-operative Rev-Rev and Rev-RNA interactions, the biological function of Rev multimerization, the relevance of Rev multimerization in the absence of RRE and its potential as a therapeutic target.

Keywords: Co-operative interactions, HIV-1, multimerization, protein-protein interactions, protein-RNA interactions, Rev, RNA export, viral replication control.

Download Free Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 8
First Page: 623
Last Page: 634
Page Count: 12
DOI: 10.2174/1570162X12666140307094603
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science