Lessons Learned from HIV Vaccine Clinical Efficacy Trials

ISSN: 1873-4251 (Online)
ISSN: 1570-162X (Print)


Volume 12, 6 Issues, 2014


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Current HIV Research

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Editor-in-Chief:
Charles Wood
University of Nebraska
Lincoln, NE
USA


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Lessons Learned from HIV Vaccine Clinical Efficacy Trials

Author(s): Tracey A. Day and James G. Kublin

Affiliation: HIV Vaccine Trials Network, Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA.

Abstract

The past few years have witnessed many promising advances in HIV prevention strategies involving preexposure prophylaxis approaches. Some may now wonder whether an HIV vaccine is still needed, and whether developing one is even possible. The partial efficacy reported in the RV144 trial and the encouraging results of the accompanying immune correlates analysis suggest that an effective HIV vaccine is achievable. These successes have provided a large impetus and guidance for conducting more HIV vaccine trials. A key lesson learned from RV144 is that assessment of HIV acquisition is now a feasible and valuable primary objective for HIV preventive vaccine trials. In this article we review how RV144 and other HIV vaccine efficacy trials have instructed the field and highlight some of the HIV vaccine concepts in clinical development. After a long and significant investment, HIV vaccine clinical research is paying off in the form of valuable lessons that, if applied effectively, will accelerate the path toward a safe and effective vaccine. Together with other HIV prevention approaches, preventive and therapeutic HIV vaccines will be invaluable tools in bringing the epidemic to an end.

Keywords: Efficacy trial, HIV, HIV vaccine trials network, HVTN, HVTN 505, RV144, step study, vaccine.

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Article Details

Volume: 11
Issue Number: 6
First Page: 441
Last Page: 449
Page Count: 9
DOI: 10.2174/1570162X113116660051
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