Effects of Diabetic HDL on Endothelial Cell Function

ISSN: 2212-4063 (Online)
ISSN: 1871-529X (Print)

Volume 15, 3 Issues, 2015

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Cardiovascular & Hematological Disorders-Drug Targets

Formerly: Current Drug Targets - Cardiovascular & Hematological Disorders

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Garry X. Shen
University of Manitoba
Winnipeg, MB

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Effects of Diabetic HDL on Endothelial Cell Function

Cardiovascular & Hematological Disorders-Drug Targets, 14(2): 137-141.

Author(s): Dan He, Bing Pan, Hui Ren and Lemin Zheng.

Affiliation: The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Health Ministry, Beijing 100191, China.


Type 2 diabetes mellitus (T2DM) is accompanied by dysfunctional high-density lipoprotein (HDL) and this is characterized by alterations in its composition and structure compared with HDL from normal subjects (N-HDL). HDL from diabetic subjects (D-HDL) has a diminished endothelial protective capacity including reducted ability to exert antioxidative activity, stimulate endothelial cell (EC) production of nitric oxide (NO) and endothelium-dependent vasomotion, promote endothelial progenitor cell (EPC)-mediated endothelial repair. In addition, D-HDL promotes EC proliferation, migration and adhesion to the matrix. The present review provides an overview of these effects of diabetic HDL on EC function, as well as the possible changes of D-HDL structure and composition which may be responsible for the diminished endothelial protective capacity of D-HDL.


Diabetes mellitus, dysfunction, endothelial dysfunction, high-density lipoprotein.

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Article Details

Volume: 14
Issue Number: 2
First Page: 137
Last Page: 141
Page Count: 5
DOI: 10.2174/1871529X14666140505124415

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