Endothelial cell regulation of cardiac metabolismfollowing diabetes

ISSN: 2212-4063 (Online)
ISSN: 1871-529X (Print)

Volume 14, 3 Issues, 2014

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Cardiovascular & Hematological Disorders-Drug Targets

Formerly: Current Drug Targets - Cardiovascular & Hematological Disorders

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Garry X. Shen
University of Manitoba
Winnipeg, MB

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Endothelial cell regulation of cardiac metabolismfollowing diabetes

Author(s): F Wang, D Zhang, A Wan and B Rodrigues

Affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, B.C., Canada V6T 1Z3


The earliest change that occurs in the diabetic heart is reduced glucose consumption, with a switch to utilization of fatty acids (FA) predominantly as an energy resource. Although this adaptation might be beneficial in the short-term, over a protracted duration, it is potentially catastrophic given the malicious effects produced by high FA in cardiomyocytes. In this review, we describe how the endothelial cell (EC), a “first-responder” to hyperglycemia, communicates with the underlying cardiomyocyte. As this cross-talk is expected to facilitate increased FA delivery to, and utilization by, the cardiomyocyte, understanding this conversationshould assist in devising new therapeutic strategies to prevent or delay diabetic heart disease

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Article Details

Volume: 14
First Page: 1
Last Page: 1
Page Count: 1
DOI: 10.2174/1871529X14666140505123221

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