Histone Methylation and Transcriptional Regulation in Cardiovascular Disease

ISSN: 2212-4063 (Online)
ISSN: 1871-529X (Print)


Volume 14, 3 Issues, 2014


Download PDF Flyer




Cardiovascular & Hematological Disorders-Drug Targets

Formerly: Current Drug Targets - Cardiovascular & Hematological Disorders

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Garry X. Shen
University of Manitoba
Winnipeg, MB
Canada


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Histone Methylation and Transcriptional Regulation in Cardiovascular Disease

Author(s): Yong Xu and Fei Fang

Affiliation: 140 Hanzhong Rd, Nanjing, Jiangsu 210029, China.

Abstract

Cardiovascular disease (CVD) represents a major health risk to the global population. In disease settings, cells that constitute the vasculature undergo profound changes both morphologically and functionally paralleling alterations in gene expression profile. At the transcriptional level, gene expression is steered by the epigenetic machinery including DNA methyltransferases, histone variants, non-coding regulatory RNAs, chromatin remodeling complexes, and histone modifying enzymes. The N-terminal tails of histones, primarily histones H3 and H4, are post-translationally modified creating a unique platform for transcriptional regulation. This review summarizes our current understanding of the role of histone methylation in modulating the vascular transcriptome and its relevance in CVD with an outlook on future directions.

Keywords: Cardiovascular disease, epigenetics, histone methylation, transcriptional regulation.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 14
Issue Number: 2
First Page: 89
Last Page: 97
Page Count: 9
DOI: 10.2174/1871529X14666140505122144
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science