Iron Supplementation Therapy in End-Stage Renal Disease Patients on Maintenance Hemodialysis

ISSN: 2212-4063 (Online)
ISSN: 1871-529X (Print)

Volume 15, 3 Issues, 2015

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Cardiovascular & Hematological Disorders-Drug Targets

Formerly: Current Drug Targets - Cardiovascular & Hematological Disorders

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Garry X. Shen
University of Manitoba
Winnipeg, MB

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Iron Supplementation Therapy in End-Stage Renal Disease Patients on Maintenance Hemodialysis

Cardiovascular & Hematological Disorders-Drug Targets, 13(3): 237-242.

Author(s): Masanori Shibata and Shinkichi Taniguchi.

Affiliation: 85 Kouden, Kunotsubo, Kita- Nagoya, Aichi, Japan 481-0041.


Iron supplementation therapy seems almost indispensable in adequate management of the patients with end - stage renal disease on maintenance hemodialysis, since at least one and a half grams iron is considered to be required per year to keep sufficient erythropoiesis. Iron supplementation in conjunction with erythropoietic-stimulating agents is widely carried out as a standard therapy. However, definite diagnosis of iron deficiency in hemodialysis patients is often difficult since serum ferritin levels increase frequently by various reasons including inflammation and malignancy. Although several guidelines to treat anemia of the hemodialysis patients have been proposed, they seem still insufficient and careful clinical observation is required in individual patient to avoid possible complications of iron overload. We, here, reassess the adequate iron supplementation therapy in those patients, and the necessity of new guideline employing recent advances including magnetic resonance imaging – based method (FerriScan) and hemoglobin content per each reticulocyte is also discussed.


Erythropoietic-stimulating agents, end-stage renal disease, ferritin, iron, hemodialysis, iron deficiency, iron supplementation, iron overload.

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Article Details

Volume: 13
Issue Number: 3
First Page: 237
Last Page: 242
Page Count: 6
DOI: 10.2174/1871529X1303140129155609

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