Improvement in Lipid Profile after Vitamin D Supplementation in Indigenous Argentine School Children
Valeria Hirschler, Gustano Maccallini, Maria I. Tamborenea, Claoudio Gonzalez, Milva Sanchez, Claudia Molinari, on behalf of San Antonio de los Cobres Study Group, Luis Castano, Graciela Colque, Mariana Hidalgo and Mirta UrzagastiAffiliation:
Universidad de Buenos Aires, Maipu 812 5 M Buenos Aires (1006), Argentina.
Objective: To determine whether vitamin D supplementation of indigenous school children living at high altitude who are vitamin D insufficient improves lipid profile.
Methods: A prospective two-year study evaluated 60 children (29 males) from Hogar School who received 100,000 units of vitamin D and 36 children (16 males) from Sosa School who received 50,000 units. Anthropometric measures, Triglycerides (TG), HDL-C, TG/HDL-C, and vitamin D levels were measured in November 2011 and in November 2013.
Results: Children aged 8.8±2 years with mean z-BMI (-0.43) were evaluated. After vitamin D supplementation, mean vitamin D levels increased from 14.7 to 32.1ng/mL (p<0.01) in Hogar and from 14.6 to 25.1ng/mL (p<0.01) in Sosa School. Furthermore, mean HDL-C increased significantly in Hogar (39.8 to 43.9 mg/dL); while no significant changes were found in Sosa School (44.4 to 45.1mg/dL). Though no significant changes were found in median TG (117 to 111 mg/dL) and TG/HDL (3.0 to 2.7 mg/dL) in Hogar; TG (95 to 111 mg/dL) and TG/HDL-C (2.2 to 2.4 mg/dL) increased significantly in Sosa School. Several multiple linear regression analyses showed that children from Hogar School decreased TG/HDL-C by 1.3 mg/dL (R2: 0.14), HDL-c by 3.6 mg/dL (R2: 0.13), and TG by 31mg/dL (R2: 0.11), adjusted for confounding factors.
Conclusions: Indigenous children who received 100,000 U of vitamin D significantly improved vitamin D and lipid levels compared to children who received 50,000 U, suggesting that optimal vitamin D levels are associated with a healthier lipid profile.
Indigenous school children, lipid profile, Vitamin D supplementation.
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