Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics

ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)

Volume 17, 6 Issues, 2017

Download PDF Flyer

Current Gene Therapy

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 81st of 167 in Genetics & Heredity

Submit Abstracts Online Submit Manuscripts Online

L.-J. Chang
University of Florida
Gainesville, FL

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.738
5 - Year: 3.186

Gene Therapy: The Role of Cytoskeleton in Gene Transfer Studies Based on Biology and Mathematics

Current Gene Therapy, 14(2): 121-127.

Author(s): Maria G. Notarangelo, Roberto Natalini and Emanuela Signori.

Affiliation: Laboratory of Molecular Pathology and Experimental Oncology, CNR-IFT, via Fosso del Cavaliere 100, 00133, Rome, Italy.


Gene therapy is a promising approach for treating a wide range of human pathologies such as genetic disorders as well as diseases acquired over time. Viral and non-viral vectors are used to convey sequences of genes that can be expressed for therapeutic purposes. Plasmid DNA is receiving considerable attention for intramuscular gene transfer due to its safety, simplicity and low cost of production. Nevertheless, strategies to improve DNA uptake into the nucleus of cells for its expression are required. Cytoskeleton plays an important role in the intracellular trafficking. The mechanism regulating this process must be elucidated. Here, we propose a new methodological approach based on the coupling of biology assays and predictive mathematical models, in order to clarify the mechanism of the DNA uptake and its expression into the cells. Once these processes are better clarified, we will be able to propose more efficient therapeutic gene transfer protocols for the treatment of human patients.


Gene therapy, intracellular transport, mathematical models, microtubules, plasmid DNA.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 14
Issue Number: 2
First Page: 121
Last Page: 127
Page Count: 7
DOI: 10.2174/1566523214666140305223251
Price: $58

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science