MicroRNA Pathways: An Emerging Role in Identification of Therapeutic Strategies

ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)


Volume 16, 6 Issues, 2016


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Current Gene Therapy

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Editor-in-Chief:
L.-J. Chang
University of Florida
Gainesville, FL
USA


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MicroRNA Pathways: An Emerging Role in Identification of Therapeutic Strategies



Current Gene Therapy, 14(2): 112-120.

Author(s): Soundararajan Vijayarathna, Chern E. Oon, Subramanion L. Jothy, Yeng Chen, Jagat R. Kanwar and Sreenivasan Sasidharan.

Affiliation: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.

Abstract

For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are generated and function will help with diagnostic tools and therapeutic strategies. This review encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs.

Keywords:

miRNA biogenesis, canonical pathways, non-canonical pathways, circulating miRNAs.



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Article Details

Volume: 14
Issue Number: 2
First Page: 112
Last Page: 120
Page Count: 9
DOI: 10.2174/1566523214666140302192953
Price: $58
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