The Inhibitory Effect of Some Algerian Plants Phenolics Extracts on the α - glucosidase and α - amylase Activities and their Antioxidant Activities

ISSN: 1875-6662 (Online)
ISSN: 1573-4080 (Print)


Volume 10, 2 Issues, 2014


Download PDF Flyer




Current Enzyme Inhibition

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece
Email: hadjipav@pharm.auth.gr

View Full Editorial Board

Subscribe Purchase Articles Order Reprints


The Inhibitory Effect of Some Algerian Plants Phenolics Extracts on the α - glucosidase and α - amylase Activities and their Antioxidant Activities

Author(s): Ihcen Khacheba, Amar Djeridane, Abdelkarim Kameli and Mohamed Yousfi

Affiliation: Laboratoire des Sciences Fondamentales, Université Amar Telidji. Laghouat- Algérie.

Abstract

The aim of this study consisted in extracting and quantifying phenolic and flavonoids compounds of five selected Algerian plants. The second step was devoted to studying the effects of phenolic compounds on the kinetics catalyzed by two enzymes belonging to the class of hydrolase (the α - amylase and the α - glucosidase) responsible for the digestion of sugars. Finally, we assessed the potential antiradical of our extracts.

The results indicate that the phenolic extracts from these plants have inhibitory effects on both enzymes, with Ki values in µg/ml range (18.19-72.14 µg / ml) for the α - amylase and (52.26 - 203.90 µg / ml) for α – glucosidase. The antioxidant activity test shows that our phenolic extracts exhibit good antioxidant capacity comparatively to antioxidants taken as reference with IC50 values which vary from 0.044 µg / ml to 0.452 µg / ml. This work contributes to understanding the role of natural polyphenols in the regulation of oxidative stress and normalization of glycemic disorders.


Keywords: α - amylase, α - glucosidase, antioxidant activity, DPPH, inhibition effect, Phenolic extracts.

Download Free Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 10
Issue Number: 1
First Page: 59
Last Page: 68
Page Count: 10
DOI: 10.2174/15734080113099990001
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science