Mitochondrial Membrane Lipids in Life and Death and their Molecular Modulation by Diet: Tuning the Furnace

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)

Volume 18, 16 Issues, 2017

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Current Drug Targets

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Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Mitochondrial Membrane Lipids in Life and Death and their Molecular Modulation by Diet: Tuning the Furnace

Current Drug Targets, 15(8): 797-810.

Author(s): Joao P. Monteiro, Catarina M. Morais, Paulo J. Oliveira and Amalia S Jurado.

Affiliation: CNC - Center for Neuroscience and Cell Biology, UC Biotech Building, University of Coimbra, Lot 8A, Biocant Park, 3060-197 Cantanhede, Portugal.


The traditional view of mitochondria as cell powerhouses is a matter of common knowledge, but the overall view of these extraordinary organelles has been revolutionized in the last years. In fact, a large number of important and diverse processes take place at the mitochondrial level, which clearly surpass the energy production scope, intruding the critical fragile balance between cell life and death. The entangled biochemistry of mitochondrial membranes has been found to be dependent on specific lipid requirements, with cardiolipin holding a great part of the raised functional interest. Mitochondria contain a complex membrane system, based on a variety of lipids and exquisite asymmetries. Mitochondria lipid membrane composition depends on a tight interplay with the endoplasmic reticulum, from which some of the lipids present in the mitochondrial membranes have to be imported, at least in the form of precursors. Here, we review some external interventions resulting in alterations of mitochondrial lipid content, namely dietary interventions and genetic manipulation. Such manipulations of mitochondrial membrane lipid composition should result in physiological impact, given the importance of lipid-protein interactions within the mitochondrial membrane boundaries. We provide arguments for future experiments using the most modern chemical and biophysical approaches as well as computer simulation studies applied to appropriate biological membrane model systems, in order to identify the effects exerted by diet-induced lipid changes on membrane physical properties.


Apoptosis, cardiolipin, diet, lipid-protein interactions, membrane lipid remodelling, mitochondrial membrane asymmetries, mitochondrial phospholipid synthesis.

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Article Details

Volume: 15
Issue Number: 8
First Page: 797
Last Page: 810
Page Count: 14
DOI: 10.2174/1389450115666140623115315
Price: $58

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