Synthetic Glycosylated Natural Products Have Satisfactory Activities

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)


Volume 15, 14 Issues, 2014


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Editor-in-Chief:
Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
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230 Raclin-Carmichael Hall, University of Notre Dame
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Synthetic Glycosylated Natural Products Have Satisfactory Activities

Author(s): Gangliang Huang and Xinya Mei

Affiliation: College of Chemistry, Chongqing Normal University, Chongqing 401331, China.

Abstract

Many natural products contain sugar residues, which are essential components for great medicinal importance. The sugar moieties can improve water-solubility of natural products and decrease their toxicity. At the same time, the glycosidic residues are crucial for the activities of natural products. Much effort has been expended over the past decades in developing novel and efficient methodologies to synthesize the glycosylated natural products. This review highlights recent developments in the synthesis of glycosylated natural products. The structure-activity relationships of some of these glycosylated natural products, together with the structure characteristics of their interaction with the biological targets, are also involved.




Keywords: Activities, glycosylated natural products, recent development, total synthesis.

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Article Details

Volume: 15
Issue Number: 8
First Page: 780
Last Page: 784
Page Count: 5
DOI: 10.2174/1389450115666140617153348
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