Therapeutic Modulation of Gut Microbiota: Current Clinical Applications and Future Perspectives

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)

Volume 18, 16 Issues, 2017

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Current Drug Targets

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Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Current: 3.029
5 - Year: 3.341

Therapeutic Modulation of Gut Microbiota: Current Clinical Applications and Future Perspectives

Current Drug Targets, 15(8): 762-770.

Author(s): Gianluca Ianiro, Stefano Bibbò, Antonio Gasbarrini and Giovanni Cammarota.

Affiliation: Institute of Internal Medicine Catholic University of Rome, Italy, Largo A. Gemelli, 8 - 00168 - Roma, Italia.


Human beings and gut microbiota are in a symbiotic relationship, and the hypothesis of a “super organism” composed of the human organism and microbes has been recently proposed. The gut microbiota fulfills important metabolic and immunological tasks, and the impairment of its composition might alter homeostasis and lead to the development of microbiota-related diseases. The most common illnesses associated with alterations of the gut microbiota include inflammatory bowel disease, gastroenteric infections, irritable bowel syndrome and other gastrointestinal functional diseases, colorectal cancer, metabolic syndrome and obesity, liver diseases, allergic diseases, and neurological diseases such as autism. In theory, every disease associated with the impairment of intestinal microflora might benefit from the therapeutic modulation of the gut microbiota. A number of attempts to manipulate the microbiota have not produced identical results for every disease. Although antibiotics and probiotics have been available for a long time, the so-called fecal microbiota transplantation, which is a very old remedy, was only recently re-evaluated as a promising therapeutic approach for microbiota impairment. A comprehensive understanding of the gut microbiota composition, in states of both health and various diseases, is needed for the development of future approaches for microbiota modulation and for developing targeted therapies. In this review, we describe the role of the microbiota in several diseases and the related treatment options that are currently available.


Antibiotics, fecal microbiota transplantation, gut microbiota, modulation, probiotics, therapy.

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Article Details

Volume: 15
Issue Number: 8
First Page: 762
Last Page: 770
Page Count: 9
DOI: 10.2174/1389450115666140606111402
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

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