A Review on Skin Targeted Delivery of Bioactives as 2 Ultradeformable Vesicles: Overcoming the Penetration Problem

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)

Volume 16, 14 Issues, 2015

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Current Drug Targets

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Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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A Review on Skin Targeted Delivery of Bioactives as 2 Ultradeformable Vesicles: Overcoming the Penetration Problem

Current Drug Targets, Volume 14 (E-pub ahead of print)

Author(s): Priyanka Karunanidhi and Singh Sanjay.

Affiliation: Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi – 221005 (U.P), India.


Administration of drugs through skin via transdermal route is a non-invasive approach and applicable for systemic delivery but it is not suitable for drugs having higher molecular weight. Many approaches have been used to improve the efficacy of transdermal route such as vesicular approach, iontophoresis, microneedles, use of permeation enhancers, etc. Among the several approaches, vesicular delivery is gaining importance in transdermal drug delivery. Transfersomes are one of the vesicular systems and best suited for transdermal delivery of higher molecular weight compounds. Due to the deformability nature of transfersomes, it penetrates into deeper layers of skin, after penetration retains its original structure and finally 9enters into the systemic circulation. This review focuses mainly on applications of transfersomes in the field of drug delivery i.e. delivery of analgesics, anti-cancers, proteins and peptides, immunomodulators, steroidal hormones and herbal drugs with increased penetration through skin. In addition, this review also deals with preparation methods available for preparing transfersomes, characterization, mechanism of penetration upon topical application and its kinetic aspects.

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Article Details

Volume: 14
First Page: 1
Page Count: 1
DOI: 10.2174/13894501113149990201
RNA Therapeutics

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