Cyclization in opioid peptides

ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)

Volume 15, 14 Issues, 2014

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Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Cyclization in opioid peptides

Author(s): Justyna Piekielna, Renata Perlikowska, Katarzyna Gach and Anna Janecka

Affiliation: Department of Biomolecular Chemistry, Medical University of Lodz, Lodz, Poland


Endogenous opioid peptides have been studied extensively as potential therapeutics for the treatment of pain. The major problems with using natural opioid peptides as drug candidates are their poor receptor specificity, metabolic instability and inability to reach the brain after systemic administration. A lot of synthetic efforts have gone into obtaining opioid analogs with improved pharmacological properties. One important structural modification leading to such analogs is cyclization of linear sequences. Intramolecular cyclization has been shown to improve biological properties of various bioactive peptides. Cyclization reduces conformational freedom responsible for the simultaneous activation of two or more receptors, increases metabolic stability and lipophilicity which may result in a longer half-life and easier penetration across biological membranes. This review deals with various strategies that have been employed to synthesize cyclic analogs of opioid peptides. Discussed are such bridging bonds as amide and amine linkages, sulfur-containing bonds, including monosulfide, disulfide and dithioether bridges, bismethylene bonds, monosulfide bridges of lanthionine and, finally, carbonyl and guanidine linkages. Opioid affinities and activities of cyclic analogs are given and compared with linear opioid peptides. Analgesic activities of analogs evaluated in the in vivo pain tests are also discussed.

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Article Details

Volume: 14
First Page: 1
Page Count: 1
DOI: 10.2174/13894501113149990005

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