Clozapine Safety, 40 Years Later

ISSN: 2212-3911 (Online)
ISSN: 1574-8863 (Print)

Volume 12, 3 Issues, 2017

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Current Drug Safety

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Dr. Seetal Dodd
University of Melbourne
Geelong, 3220

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Clozapine Safety, 40 Years Later

Current Drug Safety, 9(3): 163-195.

Author(s): Michele Raja and Silvia Raja.

Affiliation: Prisciano 26, 00136 - Roma, Italy.


Clozapine is, and will remain in the coming years, an irreplaceable drug in psychiatry which has elective indication in treatment-resistant schizophrenia, suicide risk in schizophrenia spectrum disorders, aggressiveness or violence in psychiatric patients, psychosis in Parkinson’s disease, prevention and treatment of tardive dyskinesia. Unfortunately, the drug is largely underused for many and serious side effects. Only a good knowledge of these side effects and of the main strategies to prevent their occurrence or minimize their impact can allow overcoming the underutilization of this valuable therapy.

The article describes the clinical and epidemiological features of the non-motor side effects of clozapine including blood dyscrasias, constipation, diabetes, enuresis, fever, hepatitis, hypersalivation, ileus, myocarditis, nephritis, priapism, seizures, serositis, weight gain and metabolic syndrome. The paper suggests several strategies, supported by scientific evidence, in the management of these side effects. The neuropsychiatric side effects of clozapine are not discussed in this review.


Clozapine, schizophrenia, side effects, treatment.

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Article Details

Volume: 9
Issue Number: 3
First Page: 163
Last Page: 195
Page Count: 33
DOI: 10.2174/1574886309666140428115040
Price: $58

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