Selective Serotonin Reuptake Inhibitors for Premature Ejaculation: Review of Erectile and Ejaculatory Side Effects

ISSN: 2212-3911 (Online)
ISSN: 1574-8863 (Print)

Volume 12, 3 Issues, 2017

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Current Drug Safety

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Dr. Seetal Dodd
University of Melbourne
Geelong, 3220

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Selective Serotonin Reuptake Inhibitors for Premature Ejaculation: Review of Erectile and Ejaculatory Side Effects

Current Drug Safety, 9(2): 118-126.

Author(s): George F. Lasker, Fikret Halis and Ahmet Gokce.

Affiliation: Department of Urology, Sakarya University School of Medicine, Adnan Menderes Caddesi Saglik Sokak No: 195 Adapazari, Sakarya, Turkey.


Premature ejaculation is one of the most prevalent sexual disorders affecting men today. The lack of approved therapies has resulted in the prescription of many ‘off-label’ treatments to manage the condition. Selective serotonin reuptake inhibitors have an interesting side effect of prolonging ejaculatory latency. Consequently, these agents are often considered a first line treatment for patients suffering from premature ejaculation. Erectile dysfunction is another common side effect reported by men treated with selective serotonin reuptake inhibitors. Nitric oxide is the primary mediator of erectile function. Preclinical studies have provided evidence that selective serotonin reuptake inhibitors decrease nitric oxide bioavailability. This invited mini-review aims to examine the physiology of the erectile and ejaculatory responses, discuss the indicated and ‘off-label’ clinical utility of selective serotonin reuptake inhibitors, and to summarize evidence from basic science and clinical studies pertaining to mechanisms of how selective serotonin reuptake inhibitor therapy modifies ejaculatory and erectile function.


Erectile dysfunction, PE treatment, premature ejaculation, selective serotonin reuptake inhibitor, SSRI.

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Article Details

Volume: 9
Issue Number: 2
First Page: 118
Last Page: 126
Page Count: 9
DOI: 10.2174/1574886309666140120095846
Price: $58

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